Title: Engineered biosynthesis of herboxidiene analogs for novel anti-cholesterol agents
The objective of this project is to investigate the biosynthetic pathway of the anti-cholesterol natural product herboxidiene. Based on the understanding of the biosynthetic mechanism, we will engineer the pathway to create a series of new herboxidiene analogues for new anti-cholesterol agents.
Title: Chemoenzymatic synthesis of pradimicin analogues for novel antifungal and antiviral agents
On this project, Dr. Zhan works with Dr. Tom Chang and Dr. Takemoto to understand the late biosynthetic steps of pradimicin A, and combines chemical and enzymatic approaches to synthesize new pradimicin analogues for new anti-infective agents.
Title: Mixing tetracycline and angucycline biosynthetic machineries for novel antibiotics
This project aims to engineer type II polyketide biosynthetic pathways to create new molecules for antimicrobial activity screening.